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CAS 104992-55-4 RNA Oligonucleotide Synthesis -2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

CAS 104992-55-4 RNA Oligonucleotide Synthesis -2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

Phosphoramidite rna oligonucleotide synthesis

Cyanoethyl rna oligonucleotide synthesis

Oligonucleotide cyanoethyl phosphoramidite

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Product Details
Molecular Weight:
White To Faint Yellow Powder
Molecular Formula:
CAS Number:
HPLC ≥98%
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Packaging Details
standard packing size: 5-250g/bottle
Delivery Time
4-8 work days
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1000 KG/per mouth
Product Description

-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite/C53H66N7O8PSi/HPLC ≥98%/CAS No. 104992-55-4


N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis
Uses N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses -2''O-TBDMS-rA(bz) Phosphoramidite is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Chemical Synthesis CAS 104992-55-4 RNA Oligonucleotide Synthesis -2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite 0
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 niL’) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 °C. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give A2 as a white solid (13.0 g. 86% yield)



  • Molecular Weight988.19
  • AppearanceWhite to faint yellow powder
  • Storage-20℃
  • Molecular FormulaC53H66N7O8PSi
  • CAS Number104992-55-4
  • Purity                                                HPLC ≥98%
Purity (31P NMR) ≥98%
Solvent Residue (GC) ≤3.0%w/w
Water Content ≤0.2%w/w
Clarity after dissolution (visual) The solution is clear with no insolubles

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