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OEM 2'-OMe-iBu-G-CE-RNA Phosphoramidite CAS 150780-67-9 N2-iBu-5'-O--2'-OMe-G-CE

OEM 2'-OMe-iBu-G-CE-RNA Phosphoramidite CAS 150780-67-9 N2-iBu-5'-O--2'-OMe-G-CE

OEM RNA Phosphoramidites

RNA Phosphoramidites 150780-67-9

Phosphoramidite 150780-67-9

Place of Origin:

China

Brand Name:

HUANA

Model Number:

C-040

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Product Details
Molecular Weight:
869.94
Appearance:
White Powder
Storage:
-20℃
Molecular Formula:
C45H56N7O9P
CAS Number:
150780-67-9
Purity:
HPLC ≥98%
Payment & Shipping Terms
Minimum Order Quantity
10g
Packaging Details
standard packing size: 5-250g/bottle
Delivery Time
4-8 work days
Payment Terms
T/T
Supply Ability
1000 KG/per mouth
Product Description

2'-OMe-iBu-G-CE-Phosphoramidite/N2-iBu-5'-O--2'-OMe-G-CE/HPLC ≥98%/CAS No. 150780-67-9

 

Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotection schemes that are based on the application of aliphatic amines, such as . The adenosine and guanosine monomers are protected with the standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analogue that is characterized by the exceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradation compared to natural nucleic acids. The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:

  • Diagnostic probes
  • Aptamer and ribozyme development
  • Mixed 2′O-Methyl-RNA/DNA antisense molecule

Key Features:

  • High yield of crude oligonucleotides
  • Compatible with DNA synthesis
  • Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides
  • Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous I/I, v/v) for 10 minutes at 65 °C
  • Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolyticdegradation-2′O-Methyl-rG(ib) Phosphoramidite is configured for MerMade Synthesizers.

 

  • Molecular Weight869.94
  • AppearanceWhite powder
  • Storage-20℃
  • Molecular FormulaC45H56N7O9P
  • CAS Number150780-67-9
  • PurityHPLC ≥98%
  •  
Purity (31P NMR) ≥98%

HPLC

≥98%
Solvent Residue (GC) ≤3.0%w/w
Water Content ≤0.2%w/w
Clarity after dissolution (visual) The solution is clear with no insolubles

 

 
 
5'-O-(4,4-Ditrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis
Uses 2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand.

 

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