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HPLC ≥98% -2'-O-TBDMS-A(Bz)-CE-Phosphoramidite TBDMS Reagent CAS 104992-55-4

HPLC ≥98% -2'-O-TBDMS-A(Bz)-CE-Phosphoramidite TBDMS Reagent CAS 104992-55-4

tbdms reagent

Phosphoramidite tbdms reagent

104992-55-4 Phosphoramidite

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Product Details
Molecular Weight:
White To Faint Yellow Powder
Molecular Formula:
CAS Number:
HPLC ≥98%
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Minimum Order Quantity
Packaging Details
standard packing size: 5-250g/bottle
Delivery Time
4-8 work days
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Supply Ability
1000 KG/per mouth
Product Description
  • -2'-O-TBDMS-A(Bz)-CE-Phosphoramidite/N6-Bz-5'-O--2'-O-TBDMS-A-CE/HPLC ≥98%/CAS No. 104992-55-4


  • Molecular Weight988.19
  • AppearanceWhite to faint yellow powder
  • Storage-20℃
  • Molecular FormulaC53H66N7O8PSi
  • CAS Number104992-55-4
  • PurityHPLC ≥98%


N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Basic information
Product Name: N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
Synonyms: -2′O-TBDMS-rA(bz) Phosphoramidite;2'-TBDMS -Bz-rA-CE-Phosphoramidite;5'--2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite;(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-phenyl)(phenyl))methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite;REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite;Bz-rA Phosphoramidite;N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O--adenosine 3'-CE phosphoramidite;5'-O-(4,4'-Di)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
CAS: 104992-55-4
MF: C53H66N7O8PSi
MW: 988.19
N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis
Uses N-Benzoyl-5'-O-(4,4-Ditrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses -2''O-TBDMS-rA(bz) Phosphoramidite is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Chemical Synthesis HPLC ≥98% -2'-O-TBDMS-A(Bz)-CE-Phosphoramidite TBDMS Reagent CAS 104992-55-4 0
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 niL’) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 °C. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give A2 as a white solid (13.0 g. 86% yield)

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