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Product Details:
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| Molecular Weight: | 988.19 | Appearance: | White To Faint Yellow Powder |
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| Storage: | -20℃ | Molecular Formula: | C53H66N7O8PSi |
| CAS Number: | 104992-55-4 | Purity: | HPLC ≥98% |
| High Light: | Phosphoramidite rna oligonucleotide synthesis,Cyanoethyl rna oligonucleotide synthesis,Oligonucleotide cyanoethyl phosphoramidite |
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DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite/C53H66N7O8PSi/HPLC ≥98%/CAS No. 104992-55-4
| N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis |
| Uses | N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes. |
| Uses | DMT-2''O-TBDMS-rA(bz) Phosphoramidite is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus. |
| Chemical Synthesis |  To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 niL’) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 °C. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give A2 as a white solid (13.0 g. 86% yield) |
| Purity (31P NMR) | ≥98% |
| Solvent Residue (GC) | ≤3.0%w/w |
| Water Content | ≤0.2%w/w |
| Clarity after dissolution (visual) | The solution is clear with no insolubles |
Contact Person: Lara He
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