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CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

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CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite
CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

Large Image :  CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

Product Details:
Place of Origin: China
Brand Name: HUANA
Model Number: C-034
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Packaging Details: standard packing size: 5-250g/bottle
Delivery Time: 4-8 work days
Payment Terms: T/T
Supply Ability: 1000 KG/per mouth

CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite

Description
Molecular Weight: 988.19 Appearance: White To Faint Yellow Powder
Storage: -20℃ Molecular Formula: C53H66N7O8PSi
CAS Number: 104992-55-4 Purity: HPLC ≥98%
High Light:

Phosphoramidite rna oligonucleotide synthesis

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Cyanoethyl rna oligonucleotide synthesis

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Oligonucleotide cyanoethyl phosphoramidite

DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite/C53H66N7O8PSi/HPLC ≥98%/CAS No. 104992-55-4

 

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis
Uses N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses DMT-2''O-TBDMS-rA(bz) Phosphoramidite is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Chemical Synthesis CAS 104992-55-4 RNA Oligonucleotide Synthesis DMT-2'-O-TBDMS-A(Bz)-CE-Cyanoethyl Phosphoramidite 0
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 niL’) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 °C. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give A2 as a white solid (13.0 g. 86% yield)

 

 

  • Molecular Weight988.19
  • AppearanceWhite to faint yellow powder
  • Storage-20℃
  • Molecular FormulaC53H66N7O8PSi
  • CAS Number104992-55-4
  • Purity                                                HPLC ≥98%
Purity (31P NMR) ≥98%
Solvent Residue (GC) ≤3.0%w/w
Water Content ≤0.2%w/w
Clarity after dissolution (visual) The solution is clear with no insolubles
 

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